A PROMIS Measure of Neuropathic Pain Quality.

TitleA PROMIS Measure of Neuropathic Pain Quality.
Publication TypeJournal Article
Year of Publication2016
AuthorsAskew RL, Cook KF, Keefe FJ, Nowinski CJ, Cella D, Revicki DA, DeWitt EMMorgan, Michaud K, Trence DL, Amtmann D
JournalValue Health
Volume19
Issue5
Pagination623-30
Date Published2016 Jul-Aug
ISSN1524-4733
KeywordsAdult, Aged, Female, Humans, Male, Middle Aged, Neuralgia, Pain Measurement, Quality of Life, Self Report, Treatment Outcome
Abstract

OBJECTIVES: Neuropathic pain (NP) is a consequence of many chronic conditions. This study aimed to develop an unidimensional NP scale with scores that represent levels of NP and distinguish between individuals with NP and non-NP conditions.
METHODS: A candidate item pool of 42 pain quality descriptors was administered to participants with osteoarthritis, rheumatoid arthritis, diabetic neuropathy, and cancer chemotherapy-induced peripheral neuropathy. A subset of pain quality descriptors (items) that best distinguished between participants with and those without NP conditions were identified. Dimensionality of pain descriptors was evaluated in a development sample and cross-validated in a holdout sample. Item responses were calibrated using an item response theory model, and scores were generated on a T-score metric. NP scale scores were evaluated in terms of the reliability, validity, and ability to distinguish between participants with and without conditions typically associated with NP.
RESULTS: Of the 42 initial items, 5 were identified for the Patient-Reported Outcome Measurement Information System (PROMIS) Neuropathic Pain Quality Scale. T scores exhibited good discriminatory ability on the basis of receiver-operator characteristic analysis. Score thresholds that optimize sensitivity and specificity were identified. Construct, criterion, and discriminant validity, and reliability of scale scores were supported.
CONCLUSIONS: The five-item Patient-Reported Outcome Measurement Information System (PROMIS PQ-Neuro) Neuropathic Pain Quality Scale is a short and practical measure that can be used to identify patients more likely to have NP and to distinguish levels of NP. The data collected will support future research that targets other unidimensional pain quality domains (e.g., nociceptive pain).

DOI10.1016/j.jval.2016.02.009
Alternate JournalValue Health
PubMed ID27565279
PubMed Central IDPMC5002873
Grant ListP30 CA060553 / CA / NCI NIH HHS / United States
U01 AR052177 / AR / NIAMS NIH HHS / United States
U2C CA186878 / CA / NCI NIH HHS / United States