PROMIS measures of pain, fatigue, negative affect, physical function, and social function demonstrated clinical validity across a range of chronic conditions.

TitlePROMIS measures of pain, fatigue, negative affect, physical function, and social function demonstrated clinical validity across a range of chronic conditions.
Publication TypeJournal Article
Year of Publication2016
AuthorsCook KF, Jensen SE, Schalet BD, Beaumont JL, Amtmann D, Czajkowski S, DeWalt DA, Fries JF, Pilkonis PA, Reeve BB, Stone AA, Weinfurt KP, Cella D
JournalJ Clin Epidemiol
Volume73
Pagination89-102
Date Published2016 May
ISSN1878-5921
KeywordsActivities of Daily Living, Adolescent, Adult, Affect, Aged, Chronic Disease, Chronic Pain, Comorbidity, Comparative Effectiveness Research, Fatigue, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, National Institutes of Health (U.S.), Pain Measurement, Psychometrics, Reproducibility of Results, Self Report, Social Behavior, Surveys and Questionnaires, United States, Young Adult
Abstract

OBJECTIVE: To present an overview of a series of studies in which the clinical validity of the National Institutes of Health's Patient Reported Outcome Measurement Information System (NIH; PROMIS) measures was evaluated, by domain, across six clinical populations.
STUDY DESIGN AND SETTING: Approximately 1,500 individuals at baseline and 1,300 at follow-up completed PROMIS measures. The analyses reported in this issue were conducted post hoc, pooling data across six previous studies, and accommodating the different designs of the six, within-condition, parent studies. Changes in T-scores, standardized response means, and effect sizes were calculated in each study. When a parent study design allowed, known groups validity was calculated using a linear mixed model.
RESULTS: The results provide substantial support for the clinical validity of nine PROMIS measures in a range of chronic conditions.
CONCLUSION: The cross-condition focus of the analyses provided a unique and multifaceted perspective on how PROMIS measures function in "real-world" clinical settings and provides external anchors that can support comparative effectiveness research. The current body of clinical validity evidence for the nine PROMIS measures indicates the success of NIH PROMIS in developing measures that are effective across a range of chronic conditions.

DOI10.1016/j.jclinepi.2015.08.038
Alternate JournalJ Clin Epidemiol
PubMed ID26952842
PubMed Central IDPMC5131708
Grant ListR01 CA160671 / CA / NCI NIH HHS / United States
U01 AR052170 / AR / NIAMS NIH HHS / United States
U01 AR057929 / AR / NIAMS NIH HHS / United States
U01 AR052181 / AR / NIAMS NIH HHS / United States
U01 AR057954 / AR / NIAMS NIH HHS / United States
U01 AR057940 / AR / NIAMS NIH HHS / United States
U01 AR052177 / AR / NIAMS NIH HHS / United States
R01 CA060068 / CA / NCI NIH HHS / United States
U01 AR057948 / AR / NIAMS NIH HHS / United States
U01 AR057956 / AR / NIAMS NIH HHS / United States
U01 AR052158 / AR / NIAMS NIH HHS / United States
U01 AR057971 / AR / NIAMS NIH HHS / United States
P30 CA060553 / CA / NCI NIH HHS / United States
U01 AR057967 / AR / NIAMS NIH HHS / United States
U01 AR052155 / AR / NIAMS NIH HHS / United States
U54 AR057943 / AR / NIAMS NIH HHS / United States
U01 AR052171 / AR / NIAMS NIH HHS / United States
U01 AR057936 / AR / NIAMS NIH HHS / United States
U01 AR052186 / AR / NIAMS NIH HHS / United States
U54 AR057951 / AR / NIAMS NIH HHS / United States
U54 AR057926 / AR / NIAMS NIH HHS / United States